Biotechnology
severe)
Phase I PK trials in patients with renal and hapatic impairment (mild
Translational medicine
Adaptive design protocols
moderate
Phase III trials with an exploratory/PK subgroup
DDI trials in patients
Phase I and II pediatric studies
Proof of Mechanism trials
Phase IIa trials
BE studies in patients
QTc trials in patients
First into Patients Phase Ib SAD/MAD trials
Proof of Concept studies