BE studies in patients
severe)
Biotechnology
Phase IIa trials
Phase I and II pediatric studies
QTc trials in patients
Adaptive design protocols
Proof of Concept studies
Proof of Mechanism trials
First into Patients Phase Ib SAD/MAD trials
Translational medicine
DDI trials in patients
Phase I PK trials in patients with renal and hapatic impairment (mild
Phase III trials with an exploratory/PK subgroup
moderate